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Custom · co-formulated copper-peptide blend to brand spec
Overview
The GHK / AHK-Cu blend is a made-to-order co-formulation of the two production Cupratec copper tripeptides — GHK-Cu and AHK-Cu — supplied at a brand-specified ratio rather than as a fixed catalogue molecule. It exists because the two complexes are mutually compatible in a shared carrier: both wrap a single Cu(II) through the histidine imidazole and a deprotonated peptide-bond nitrogen, and an ingredient house building a combined skin-and-scalp monograph can specify both actives in one base without coordination-chemistry conflict, provided the chelator and pH guardrails are honoured uniformly. Rather than ask a formulator to dose two separate powders, Cupratec coordinates and blends them to the agreed proportion. Because a blend is defined by its ratio and its components, it is not a single chemical entity — so there is no single blend-level CAS or MW; the constituent identities (GHK-Cu, CAS 89030-95-5; AHK-Cu) and the as-blended ratio are recorded on the batch COA. This is a custom, made-to-order active from the Cu-peptide programme — from 25 g pilot scale through release, co-formulated to a brand's own monograph. Cupratec agrees the GHK-Cu:AHK-Cu ratio, the intended carrier chemistry, and the fill format with the customer, then blends from the same release-grade lots used for the stocked single actives. Each commissioned blend lot carries the per-component copper-content and HPLC data, a UV-Vis read confirming both copper coordinations are intact in the combined material, the measured blend ratio as-produced, and a CIELAB ΔE colour reference for the blend so the customer's QC has a colour anchor for incoming lots. The two actives are documented individually and as the blend, so a brand can hold the combined material against both the component specs and the blend spec. Cupratec supplies it strictly as a cosmetic active; efficacy and any cosmetic claim a finished product makes are the brand's responsibility under its destination-market rules. The coordination-compatibility and lot-release logic is the same as for the single actives — see our Cu²⁺ : peptide ratio field note.
Who buys this, and why
Cosmetic-peptide buyers fall into two groups: established beauty / med-aesthetic brands extending an existing line, and private-label clients building a catalog from scratch. The first group usually wants lyophilized peptide material plus stability data in their existing carrier matrix; the second usually wants a finished formulation under their label. Both need INCI naming verified, regulator-specific safety files (CPNP for EU, FDA OTC monograph for US where relevant), and packaging-compatibility data.
Primary buyer fit: medical aesthetic clinics and med spas and regional distributors and re-sellers.
Specifications
Documentation available on request
Regulatory note
Custom · made to order · from 25 g pilot scale. The GHK / AHK-Cu blend is a brand-spec co-formulation of two cosmetic actives, not a single chemical entity; it is not assigned a blend-level catalogue CAS or MW — the component identities (GHK-Cu CAS 89030-95-5; AHK-Cu) and the as-blended ratio are recorded on the batch COA. Supplied as cosmetic actives only, not for compounded human-use preparations. Finished-product cosmetic claims are the brand's to substantiate under its destination-market rules.
Frequently asked questions
Because a blend is a mixture, not a molecule. The GHK / AHK-Cu blend is two distinct coordination compounds — GHK-Cu and AHK-Cu — combined at a brand-specified ratio, so it has no single CAS number or molecular weight of its own. What it has instead is a defined composition: the constituent identities (GHK-Cu, CAS 89030-95-5; AHK-Cu) and the measured GHK-Cu:AHK-Cu ratio as produced, both recorded on the batch COA. Cupratec reports the components and the ratio rather than inventing a blend-level identifier, because that mixture record is the accurate description of what the customer receives and what their QC group should verify against.
Yes, within the same guardrails that govern either active alone. Both wrap a single Cu(II) through the histidine imidazole and a deprotonated peptide-bond nitrogen; they are mutually compatible in a shared carrier, so a combined skin-and-scalp monograph can specify both without coordination-chemistry conflict — provided the chelator and pH guardrails are applied uniformly across the base. That means no strong chelators (EDTA, DTPA) competing for the copper, reductants kept on a separate phase or downstream of the copper-peptide addition, and a near-neutral working pH held through shelf life. The blend is supplied pre-combined from release-grade single-active lots so the formulator doses one material instead of balancing two, and the UV-Vis read on each blend lot confirms both copper coordinations are intact before it ships.
The GHK-Cu:AHK-Cu ratio is agreed with the brand up front as part of its monograph, alongside the carrier chemistry and fill format. Cupratec blends from the same release-grade lots used for the stocked single actives, then characterises the combined material: per-component copper-content and HPLC data, a UV-Vis read confirming both coordinations survived blending, the measured ratio as-produced, and a CIELAB ΔE colour reference so incoming lots have a colour anchor. It runs as a custom, made-to-order active from 25 g pilot scale through release, with scale-up after the pilot blend is qualified against the brand spec. Lead time is quoted per project. Because the material is documented both per component and as the blend, a brand can hold it against the single-active specs and the blend spec at once — the same lot-release discipline described in our Cu²⁺ : peptide ratio field note.
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